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@#AIM: To observe the clinical effect of intravitreal injection of ranibizumab combined with vitrectomy in the treatment of proliferative diabetic retinopathy(PDR).<p>METHODS: A retrospective study. Sixty patients(66 eyes)with PDR who underwent vitrectomy in our hospital from May 2016 to May 2017 were divided into two groups according to different treatment methods, 30 cases(33 eyes). ranibizumab were injected into vitreous cavity 3-5d before operation in group A, but not in group B. The incidence of iatrogenic retinal holes, intravitreal hemorrhage, visual acuity and complications were compared between the two groups.<p>RESULTS:Iatrogenic retinal hiatus and intravitreal hemorrhage occurred in both groups during operation. The number of eyes with iatrogenic retinal hiatus and the incidence of intravitreal hemorrhage in group A were less than those in group B(<i>P</i><0.05). The visual acuity of group A was better than that of group B(<i>P</i><0.05). After operation, the number of eyes with intravitreal hemorrhage, high intraocular pressure and macular edema in group A was less than that in group B(<i>P</i><0.05).<p>CONCLUSION: Preoperative intravitreal injection of ranibizumab combined with vitrectomy for PDR can effectively reduce iatrogenic retinal hiatus and intravitreal hemorrhage. Postoperative complications are less, which is conducive to the recovery of patients.
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·AIM: To investigate the effects of fundus laser combined with anti-vascular endothelial growth factor (VEGF) therapy on serum levels of NOS, VEGF and IL-6 in patients with diabetic macular edema. ·METHODS:From May 2015 to May 2016,106 cases (156 eyes) of patients with diabetic macular edema in hospital were be selected as the research object. According to the random number table method,84 eyes of 56 cases were in observation group, 72 eyes of 50 cases in the control group. The control group was given retinal laser treatment, the observation group was treated by retinal laser combined with anti-VEGF therapy. We compared two groups of clinical efficiency,the best corrected visual acuity, macular thickness, complications and serum NOS,VEGF and IL-6. ·RESULTS: The best corrected visual acuity significantly increased and the macular thickness significantly decreased in the observation group (P < 0. 05). The improvement of the best corrected visual acuity and macular thickness in the observation group was obviously better than that of the control group (P<0.05). The level of NOS,VEGF and IL-6 was not different between the two groups before treatment (P>0.05). After treatment, the levels of NOS increased significantly and VEGF and IL-6 decreased significantly in the two groups (P<0.05). The improvement of serum NOS, VEGF and IL - 6 in the observation group was better than those in the control group (P < 0. 05). The total effective rate of clinical treatment in the control group (80.6%) was lower than that of the observation group (94. 0%, P<0. 05). The incidence of complications in the control group (9.7%) and the incidence of complications in the observation group (7.1%) were not significantly different (P>0.05). ·CONCLUSION:This is a safe and effective treatment of fundus laser combined with anti - VEGF drugs in the treatment of diabetic macular edema. It can effectively improve serum NOS,VEGF and IL-6 levels.
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AIM:To investigate the dry eye prevalence, tear film function and corneal status in patients with thyroid associated ophthalmopathy ( TAO) .?METHODS: Totally 218 patients ( 436 eyes ) with TAO admitted to our hospital from September 2014 to August 2016 were selected and divided into two groups according to TAO's clinical activity score ( CAS): score≥ 4 divided into active patients, 72 cases of 144 eyes;score<4 points were inactive patients, a total of 146 cases of 292 eyes;according to the patient's course of the situation was divided into three groups, less than 1a for the short course of disease, a total of 133 cases of 266 eyes;course of disease in the 1-2a in the medium course group, there were 40 eyes of 80 eyes and 45 eyes of 90 eyes in more than 2a, as long course group. Contrast patients were examined by corneal fluorescein staining ( FL) , tear film break-up time ( BUT ) and tear secretion test ( SⅠt ) Happening.?RESULTS: In 218 patients, 138 cases of 276 eyes were diagnosed as dry eye. The prevalence rate of active period patients was higher than that of inactive patients, and the difference was statistically significant (P<0. 05). The prevalence rate in the short course group was higher than that of the middle course group and the long course group, and the difference was statistically significant compared with that in long course group (P<0. 05). There was no significant difference between any two of the three groups in BUT and SⅠt detection (P>0. 05), and the differences was statistically significant in the detection of FL (P<0. 05). The differences of FL, BUT and SⅠt between the inactive patients and the active patients were statistically significant (P<0. 05).? CONCLUSION: Most patients with TAO have inadequate tear secretion and tear film instability. The corneal epithelium of 1/3 TAO patients is damaged and the incidence of dry eye disease is significantly higher than that of normal subjects.